Which is a typical presenting symptom of Guillain-Barre' Syndrome?

Which is a typical presenting symptom of Guillain-Barre' Syndrome?

• A. Opisthotonos
• B. Seizures
• C. Paresthesia
• D. Hemiplegia

Answer: (C)

Guillain-Barré Syndrome often starts with sensory complaints before notable weakness. Paresthesias—tingling or numbness in the toes and fingers—reflect early involvement of sensory nerves and are a common presenting feature, with motor weakness typically developing and progressing afterward. In contrast, opisthotonos is more associated with severe tetanus or certain CNS conditions, seizures are not typical in GBS, and hemiplegia suggests a focal brain lesion like a stroke rather than a peripheral nerve process. So paresthesia fits the initial presentation pattern of this syndrome best.