Which statement best describes GLUT4 translocation in skeletal muscle with training?

Which statement best describes GLUT4 translocation in skeletal muscle with training?

• A. GLUT4 translocation is inhibited by training.
• B. Increases GLUT4 translocation to the membrane during and after exercise.
• C. GLUT4 is expressed only in adipose tissue.
• D. GLUT4 does not affect glucose uptake.

Answer: (B)

Training increases the movement of GLUT4-containing vesicles to the muscle cell surface in skeletal muscle during and after exercise, which boosts glucose entry into the cells. When muscles contract, a signaling cascade (including factors like AMPK and calcium signals) promotes GLUT4 translocation to the membrane, creating more gateways for glucose to be taken up. With regular training, both the amount of GLUT4 present and the efficiency of its movement to the surface improve, so glucose uptake is enhanced not only at the moment of exercise but also in the recovery period. This explains why trained individuals show better glucose disposal and insulin sensitivity. It’s not true that GLUT4 translocation is inhibited by training, nor that GLUT4 is exclusive to adipose tissue, and GLUT4 activity does affect glucose uptake.